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2020cures.com is (amplifying) Stanford’s 20 yr old disease research/cures program (protein)FoldingAthome
by
filling buildings (across the US) with donated used servers & PC’s & (Donation link) for electricity, staff, etc.
This includes: Cancers, Alzheimer’s, Parkinson’s, Lou Gehrig’s(ALS), Covid 19 variants, diabetes, fibromyalgia
Most PC’s run this PART time;
there is (not) a LARGE effort to place thousands of 24/7/365 servers & PC’s (across the US) onto the problems.
& yes, we need to hire a (real) web page designer!
END Covid-19! Fund FULLTime PCs & StanfordU’sFolding@Home
YOU can help END Corona/Covid-19. Two(2)options:
1. Run Stanford U’s Foldingathome.org
or 2.
Help Fund 2020cures.com (Donation link)
so we can build out a LOT of computers
to do this FASTER
& we eat a (lot) of electricity for you.
Stats! We’ve done over 5.35 million save points, over 6,386 assigned jobs
& deal with the tech headaches.
ie: Full time running has Taken out/Kiboshed(a good %) of our low end test systems.
What the ** heck is with the name: FoldingAtHome?
Protein folding is how MOST of our biology works:
example:
MadCowDisease Prions (15 nm )are misfolded proteins with the ability to transmit their misfolded shape onto normal variants of the same protein.
Microscopes can only go down to LIGHT size. Full spectrum daylight wavelength is
360nm wide (UV 380nm-740nm IR range)
Covid virii range 60 to 140 nm (60,000-140,000 pm)
Methane 0.38nm (380 pm (1×10−12 m))
sneeze
droplet: 500nm (500,000-12,000,000 pm) (.05 to 12 μm micrometers)
Most cancer cells are 10 μm 10,000nm. But the parts INSIDE the cells: Far smaller than we can see.
SO: We use computer modeling to FOLD Atomic Level Molecules.
Bill Nye on why masks are effective:
The 1st US MANDATORY vaccination:
1777-1783 George Washington: Mandatory Smallpox vaccine or get OUT of the paid US Army.
Moderna’s 89% dropped to 58% effective.
Pfizer 87% dropped to 45%
Johnson & Johnson’s 86% to just 13%
(Published & peer-reviewed in the journal Science).
Covid:DRAMATIC decline in (current)vaccine effectiveness
(only 13-59% in all 3 COVID-19 vaccines)
Nov 8, 2021 Los Angeles Times
via a study of 780,000 US Veterans
from March to Sept (6 months).
Variants (MASSIVE # of strains to date… hint: B.1.640 ) may have large part in this.
Whitetail Deer are now confirmed carriers (where more variants form).
Of concern:
Delta, Mu, Lambda
& Delta now has a mutation AY.4.2 (Delta plus)…
We may end up w/ multiple vaccine shots per year, as this bug keeps quickly evolving.
And We (with Stanford’s program) are helping in that fight:
(Donation link)
1918: Jan 1918-Dec 1920 (3 years, 36 months)
In those 3 years they had 3 waves.
We are in the 4th wave (of ? waves)
1918 675,000 US Deaths (thru 1920)
2021 768,619 US deaths (so far)
1918 50+ million deaths worldwide
1918 US population 103 million
2020 US population 331 million
1918 World Population 1.8 billion
2021 World Population 7.8 billion
Corona/ H1N1 / SARS are of the same viral family
1918: H1N1 influenza (of avian origin)
So- what IS this?
Distributed Computing:
Folding@home breaks BIG data projects into (4 – 48hr) – week-long jobs, to a GIANT network of normal PCs:
F@H uses extra computer time (screen savers or slow backgrounds) on millions of PC’s.
There are far fewer FULL-Time/dedicated PC’s.
We have some geeky topics to cover, so…. if you want to jump down to the (Donation link), at ANY time, we (& my other gents’ wives!) perfectly understand!
Pre:EndOfTheWorld we were starting www.TontosRoadHouse.com
(an Activist restaurant that Funds Activists, esp. w/ Native American issues)
Stanford’s FoldingAtHome
stared out in Our geek year of y2k: 2000.
Want to specify what type of disease your money goes towards?
Want to see the range of diseases F@H’s been running for 20 years?
Cancers(mult. vectors)
Alzheimer’s
Huntington’s
Parkinson’s
&
almost more than 8 seasons of House(!)
https://foldingathome.org/news/
What kind of people are associated w/ Stanford?
Mae Jemison(Professor, Astronaut, Physicist, the first Black woman in space), Astronaut Sally Ride (We need more women examples for girls!)
President Herbert Hoover, Elon Musk, Google’s Sergey Brin, Reid Hoffman,
Tiger Woods, Perry Mason (Raymond Burr)
AminoAcids->Proteins->Protein folding
Light waves are TOO big (imagine that!) to see at atomic/molecular level:
So F@H does computer atomic-level simulations of protein folding & interaction for thousands of variations, at EVERY option
looking for weaknesses/solutions.
COVID-19 Small Molecule Screening Simulations Running On Full Speed https://foldingathome.org/2020/03/30/new-covid-19-small-molecule-screening-simulations-are-running-on-full-foldinghome/
How to see the near invisible world: DNA animations:
Drew Berry is (THE) name in this field
1918,Sept.WW2 Victory Parade That Spread Death in Philadelphia (12,000 dead in 6 weeks) In 72 hours ALL beds 31 hospitals were filled.
1. https://daily.jstor.org/the-1918-parade-that-spread-death-in-philadelphia/
“If Covid-19 acts like other coronaviruses, “it likely isn’t going to be a long duration of immunity,”
Dr. Fauci explains. “When you look at the history of coronaviruses, the common coronaviruses that cause the common cold, the reports in the literature are that the
durability of immunity that’s protective ranges from
3 to 6 months to
almost always less than a year.
That’s not a lot of durability and protection.”
(Then
you need to create a NEW vaccine. From scratch.
ex: There are NOW hundreds (known) strains of Corona, 8 are dangerous.
Mult vaccines (will) be needed each year.
“Herd immunity” gets uglier to survive for waves 2, 3, 4 ( & ??? )
When things are SMALL like this, Nature evolves a LOT faster, by survival of the fittest to get by our immune system.
By mainly mis-copy errors.
Coronadeath,Turns “lungs into glass” (Warren, OH) Kevin Harris w/ Morning Express with Robin Meade https://youtu.be/MG0r23Uwn-M
224 F@H Disease Results to Date:
https://foldingathome.org/papers-results/
When March… went wild, we were running in our Activist restaurant’s build-out phase.
& we have extra PC’s sitting idle.
& we’re farmers turned geeks.
ie:
A few of us started as olde farmers turned IT admin/security geeks
(started w/ DOS 3.3 & Novell NetWare 3.10).
Farming thrifty repair background,
lets us find CPU/GPU(processor) upgrades
& tricks that are headaches & nightmares for… younger IT folk. (Whippersnappers!)
We’re training a new generation of tech geeks, so THIS is perfect!
Often old servers can get good upgrades w/
upgrading the right memory,
used CPU & GPU upgrades,
replace HD’s w/ SSD’s (most donated systems’ HDs are removed)
putting in liquid cooling systems;
And, everything has a starting point,
that needs help. (Donation link)
What happens when vaccines are figured out?
A. Great question!
B. Viruses do NOT stop evolving.
one we CAN live with is the common cold. evolves like crazy, but just a nuisance.
Some we had to stomp out. Polio. Small Pox. Measles.
But with easier International travel,
stomping new bugs out like the old days,
is No-where near as easy.
ALSO, that’s why out society will be slowly shifting to nanotechnology;
WW2 Manhattan project physicists Richard Feynman proposed near-atomic level machines to add to our immune systems: If nature can build it, why can’t we?
For a guy that Einstein liked to argue new ideas with,
merits some extra attention.
Esp. since he was on the Challenger Space Shuttle tragedy investigation team.
Now,
At that small of a scale, electricity jumps wire lines. a LOT.
It goes into clockmaker skills, modernized.
We’ll
be creating another nonprofit for that,
to help get kids in HS & MS into fields like nanotech.
But FIRST! Let’s get this off the ground.
As this builds in scale,
this project gets it’s own building.
(And heat other buildings in the winter).
And Ohio allows “free” solar incentives.
Wind & batteries… that’s where farm backgrounds help (note: LONG before power lines were run to farms in the 1930’40’s, we were using a diversity of windmill electric generators/systems…)
This is where we both tango:
Asking for funding:
Some as we start up
& we hope you’ll like what you see
& you’ll come aback later
& donate some more. (Donation link)
Also, we’ll be gearing up that HS & MS science education nonprofit we were talking about.
So, instead of PBS/NPR donor drives talking you to death
(I miss www.CarTalk.com -the Click & Clack brothers are still available online!)
Here’s some suggestions below.
10/25/50/100/250/1,000/10,000/ 50,000 (write in Your budget’s price: Farmer <-to-> Gov. Scale…)
Thanks kindly, folks!
Here’s looking at you!
(& to many, many cures to come, with your funding us!)